Myelin basic protein (MBP) is a major component of myelin. Increased concentrations of myelin in CSF indicate that demyelination is taking place. This process is not specific for MS, as other inflammatory diseases of the central nervous system can also elevate the amount of myelin basic protein in CSF. This test is not widely used; however, it may be used to assess disease activity in cases of established MS. Antibodies against MBP are, therefore, ELEVATED during active demyelination, and are found in MS patients as well as in patients with other inflammatory neurological disorders.
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