Tryptase, Serum


Reference Range

Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells that has been used as a marker for mast cell activation. Mast cells play a key role in allergic reactions and increase in numbers under inflammatory conditions. When activated, they release a variety of mediators that lead to the signs and symptoms of allergic reactions, such as systemic anaphylaxis. These mediators include tryptase and histamine. Therefore, tryptase is only found in the blood after these cells have been stimulated by some agonist, e.g. drugs, insect venom or food. Its levels correlate with the severity of the anaphylaxis. HIGH levels are also found in systemic mastocytosis, asthma, and urticaria. This test is useful in determining the cause of sudden, unexplained death, and prognosis of systemic mastocytosis.

Special Requirements

Sample taken as soon as possible after anaphylactic shock or state last anaphylactic shock time. 1mL serum Refrigerated

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