Tobramycin is a bactericidal aminoglycoside antibiotic which inhibits bacterial protein synthesis by binding to ribosomes. Its natural anti-bacterial spectrum includes Gram-negative and Gram-positive bacilli, and staphylococci. It is used to treat a wide variety of serious bacterial infections, such as respiratory tract infections, skin infections, urinary tract infections, and infections of the blood, abdomen or bones. Monitoring peak and trough concentrations is very important. The trough concentration (residual level) shows whether or not there is any accumulation of the drug in the kidneys or the inner ear. The peak concentration immediately after administration can be used to assess the bactericidal activity of the dose administered. HIGH concentrations of tobramycin well above the normal can cause renal and cochleovestibular toxicity.
Hemolyzed and lipemic samples are not accebtable