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The Rapid Plasma Reagin (RPR) test looks for the presence of Treponema pallidum, the bacterium that causes syphilis (a sexually transmitted disease). The term "reagin" means that this test does not look for antibodies against the actual bacterium, but rather for antibodies against substances released by cells when they are damaged by T. pallidum. Another test often used to screen for syphilis is the Venereal Disease Research Laboratory (VDRL) slide test. However, the RPR test is generally preferred due to its ease of use. How well the RPR test can detect syphilis depends on the stage of the disease. The test is most sensitive (almost 100%) during the middle stages of syphilis. It is less sensitive during the earlier and later stages of the disease. Therefore, a POSITIVE result in association with a positive syphilis-specific test indicates active syphilis infection. Some conditions may cause a FALSE POSITIVE test, including: HIV, lyme disease, certain types of pneumonia, malaria, and systemic lupus erythematosus.
Avoid lipemic and haemolysed samples.
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