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The albumin/globulin ratio (A/G) is the calculation of serum albumin compared to serum globulin level to determine whether there is an overproduction or underproduction of albumin, or gamma-globulin. A LOW A/G ratio may be due to overproduction of gamma-globulin (monoclonal/polyclonal hypergammaglobulinemia, multiple myeloma or autoimmune diseases), or due to low albumin (cirrhosis, or nephritic syndrome). A HIGH A/G ratio may be due to hypogammaglobulinemia. See Total Protein, Albumin, and Globulin, Serum.