IgG account for about 70% of all immunoglobulins and are found in both the intravascular and extravascular compartments where among other things they are responsible for neutralizing toxins. LOW levels may indicate hypogammaglobulinemia, either congenital or acquired due to protein leakage, viral infection, malignant hemopathy, a toxin, or drug toxicity. Selectively REDUCED IgG levels may be associated with IgA myeloma, nephrosis, visceral neoplasia or an isolated congenital deficiency. INCREASED levels of polyclonal IgG antibodies, with or without concomitant signs of inflammation, are observed in infections (bacterial, viral and parasitic), autoimmune disease and certain allergic responses. HIGH levels of a monoclonal IgG may be due to myeloma, benign gammopathy in an elderly subject, chronic infectious disease or a connective tissue disorder.
Serum/plasma application (IGG-2) Serum. Plasma: Li-heparin and K2-EDTA plasma CSF application (IGGC2) Cerebrospinal fluid. Urine application (IGGU2) Urine.
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