Coxsackie virus is a member of the Picornaviridae family of viruses, which can be separated into two groups, A and B, and each group has different serotypes. Infection is usually spread by fecal-oral contamination. Type A viruses usually cause hand-foot-and-mouth disease, acute hemorrhagic conjunctivitis (A24), herpangina (mainly A16), and aseptic meningitis. The presence of anti-coxsackie virus antibodies indicates past or recent infection. RISING IgG levels is suggestive of current infection with the virus.
Serum should be collected at onset of disease and then 2-4 weeks later to determine acute and convalescent titres.