Total serum bilirubin equals direct bilirubin (conjugated) plus indirect bilirubin. It is common to see high bilirubin in newborns, typically 1 to 3 days old. This is called physiologic jaundice of the newborn, since the newborn’s liver is not fully mature, and it’s unable to process the extra bilirubin. This situation usually resolves itself within a few days. INCREASED total or unconjugated bilirubin may be a result of hemolytic, sickle cell, or pernicious anemias, or a transfusion reaction; cases in which bilirubin is produced faster than the liver can metabolize it. High levels are also associated with Crigler-Najjar syndrome, Erythroblastosis fetalis, and Gilbert’s disease. Related tests: Bilirubin, Direct, Serum
Assay immediately. Avoid lipemic and haemolysed samples.