C2, 2nd Component of Complement, Serum


Reference Range

C2 is a component of the classical pathway of complement. C2 is activated by C1s, which cleaves it into two fragments, C2a and C2b. C2a then binds to C4b to form the enzyme site of C3 convertase. INCREASED levels of C2 are seen in hereditary congenital C1 deficiency. DECREASED levels are associated with congenital C2 deficiency, angioedema, autoimmune diseases, bacteraemia, viraemia, severe trauma, burns, or malnutrition. For more on the classical pathway, refer to C1q, First Component of Complement, Serum.

Special Requirements

Separate serum from cells as soon as possible and freeze immediately.

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