Liver Antigen Profile
Autoimmune liver disease, or autoimmune hepatitis (AIH), is a chronic, progressive inflammatory liver disease of unknown etiology. The tested antibodies are considered specific serological markers of autoimmune hepatitis (AIH).
What do we test for?
- Mitochondrial Fraction M2 (AMA-M2)
- Liver-Kidney Microsomes (LKM-1)
- Soluble Liver Antigen (SLA/LP)
- Liver-Cytosol-Specific (LC-1)
Clinical significance
Autoantibodies against the Mitochondrial Fraction M2 (AMA-M2) are usually associated with Primary Biliary Liver Cirrhosis (PBC).
Autoantibodies against the Liver-Kidney Microsomes (LKM-1) are usually associated withAutoimmune Hepatitis Type-2 (AIH-2). These autoantibodies are also associated withHepatitis C.
Autoantibodies against the Soluble Liver Antigen (SLA/LP) are highly associated withAutoimmune Hepatitis Type-3 (AIH-3), and have not been described in Viral Hepatitis.
Autoantibodies against the Liver-Cytosol-Specific (LC-1) are usually associated with Chronic Active Autoimmune Hepatitis Type-2 (AIH-2).
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