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biodouble check-up






B12, Homocysteine, Folic acid:


B12, homocysteine and folic acid are significant and recommended tests for heart diseases. Elevated homocysteine levels are considered as an indicator for a heart disease; therefore, folic acid and vitamin B12 supplements come in to serve the body in reducing the total homocysteine level. Both elder people and strict vegetarians are at a higher risk of B12 and folic acid deficiency.







Thyroid hormones mainly produce energy to keep the body warm as well as maintaining   the brain, heart, muscles, and other organs to carry out their normal function. Therefore, testing for TSH, FT4, FT3 and TPO is useful in detecting a thyroid dysfunction since it can result in hyperthyroidism, such as Grave’s Disease, that occurs as a consequence of excessive thyroid hormone activity. This may vary in several conditions when TSH levels is reduced and FT3 or/and FT4 levels are increased. As for hypothyroidism, there are two major forms;

  1. Hashimoto’s thyroiditis: High TSH and Low FT3 and FT4
  2. Secondary hypothyroidism: High TSH and Low FT3 or FT4
  3. High TPO.




Tumor markers


Tumor markers are substances found in the blood stream and/or urine and can be present in cancer and some non-cancerous disease cases. Tumor markers’ duty is to help identify the source of the cancer, determining how far the cancer has spread, monitoring the effectiveness of the treatment and the body’s response in addition to monitoring its recurrence. However, Tumor markers by themselves are usually not enough to diagnose or rule out cancer even if your blood test results appear normal.


Male tumor markers: TPSA, FPSA, CEA, CA-199


Most requested tumor markers for men are:

·      Prostate-Specific Antigen Total (TPSA) and Free (FPSA); frequently elevated in the blood of men who have enlarged prostate.

· Carcinoembryonic Antigen (CEA); elevated in colorectal, lung, breast, thyroid, pancreatic, liver, cervix and bladder cancer

·       CA-199; elevated in pancreatic, colorectal, and bile ducts cancer


Female tumor markers: CEA, CA-125, CA-15.3, CA-199


Most requested tumor markers for women are:

·  Carcinoembryonic Antigen (CEA); elevated in colorectal, lung, breast, thyroid, pancreatic, liver, cervix and bladder cancer

·       CA-125; elevated in ovarian cancer.

·       CA-153; elevated in breast, lung, and ovarian cancer

·       CA-199; elevated in pancreatic, colorectal, and bile ducts cancer



Inherited Cardiovascular Disease Risk factors: a panel of 12 genetic mutations to test for your predisposition to CVD


Cardiovascular disease (CVD) is a broad term used to describe a range of diseases that affect your heart or blood vessels. In general, it refers to narrowed or blocked blood vessels that lead to a heart attack, chest pain (angina) or stroke, resulting in a “heart disease”. Genetic vulnerability to cardiovascular diseases may be caused by mutations in a variety of genes that mainly involve blood coagulation, regulation of blood pressure, and metabolism of lipids, glucose, homocysteine or iron. All of these mutations are detected in the CVD risk factors profile.








Calcium, Magnesium, Phosphorus, Vitamin D


Women are four times more likely to develop osteoporosis than men due to Estrogen deficiency which is a very important cause of accelerated bone loss in women during and after menopause. Osteoporosis is a progressive condition in which bone density and structure are lost, thereby weakening the bones and making them more susceptible to fractures. From birth until the age of 17-18, bones begin growing in size and increasing in density holding more calcium – main factor needed by the bones to grow and regenerate with the help of Phosphorus – till the age of 30.  Vitamin D3 is a vital vitamin that helps the body absorb calcium and phosphorus incorporating them into the bones, while magnesium metabolizes the body’s calcium and converts dietary vitamin D to an active form. It also contributes to increased bone density to prevent the onset of osteoporosis.




B12, Folate, Ferritin, Transferrin


Anemia is a condition in which your blood has a lower than normal number of red blood cells. This condition can also occur if your red blood cells don’t contain enough hemoglobin – an iron-rich protein that gives blood its red color and helps red blood cells carry oxygen from the lungs to the rest of the body. There are several types of anemia; most common ones are Vitamin B12 deficiency anemia, folic acid deficiency anemia, and iron deficiency anemia. B12 deficiency anemia (pernicious anemia) is a condition in which the body can't make enough healthy red blood cells because it doesn't have enough vitamin B12. Folic acid deficiency anemia is a common, slowly progressive, megaloblastic anemia characterized by red blood cells that are larger than normal. Iron deficiency anemia is a condition in which the blood lacks adequate healthy red blood cells from the lack of iron. Therefore, The ferritin test measures how much iron is in storage and the transferrin takes part in the transportation of iron from the intestine into the bloodstream.  Keep in mind that severe or long-lasting anemia that lacks oxygen in the blood can damage the heart, brain, and other organs of the body causing death.




Anemia/Thyroid-combination: B12, Folate, Ferritin, TSH 


Many disease conditions are associated with thyroid diseases, but the one with the highest association is anemia. In the absence of thyroid hormones, anemia frequently develops, due to decreased need for oxygen that slows down the metabolism. B12 and folic acid, which are needed in the normal formation of red blood cells, are required for optimal nerve transmission, which is involved in the initial formation of thyroid hormone. Regression in folic acid is also associated with TSH levels. Those with low thyroid function have impaired B12 absorption, while those with high thyroid function have excessive loss of B12. Elevated ferritin levels have been recently observed in patients with hyperthyroidism, due to TSH effect on ferritin synthesis and release.



Diabetes/Thyroid combination: HbA1c, Microalbuminuria, TSH, FT4


Insulin and thyroid hormones are intimately involved in body function. Thus, excess or deficit of either of these hormones could result in the functional derangement of the other. Thyroid dysfunction studies reported increased insulin breakdown, which led to the increase of internal glucose production. A number of reports have also indicated a higher than normal prevalence of thyroid disorders in type 2 diabetic patients, with hypothyroidism being the most common disorder. Microalbuminuria is the presence of the protein albumin in the urine which is useful in the early detection of diabetes. HbA1c reveals the average blood glucose over a period of two to three months, and reflects diabetes control. The best way to initially test thyroid function is to measure TSH and FT4 levels in the blood.

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