Javascript is disabled on your browser
PATIENT Sign In
username:
password:

To obtain a Biolab ID, please contact us at (06) 590 7000
By signing in, you agree to our terms and conditions as well as our
privacy agreement.
(Read more)

Extractable Nuclear autoantibodies – ENA

The New comprehensive rheumatic profile (extractable Nuclear autoantibodies – ENA) test is now available at biolab, detecting 25 autoantibodies for a wide range of rheumatic diseases in one simple blood test.

 

What do we test for and its clinical significance:

 

Nucleosome

Positive/Negative

Antibodies against nucleosomes are found in 76% of patients with Systemic Lupus Erythematosus (SLE). These Abs have an important predictive value as they appear at an earlier stage than anti-dsDNA.

dsDNA

Positive/Negative

Antibodies against dsDNA are found in 88% of patients with Systemic Lupus Erythematosus (SLE). These antibodies represent the diagnostic markers for SLE according to ACR criteria.

Histones

Positive/Negative

Antibodies against histones are found in 74% of patients with Systemic Lupus Erythematosus. 95% in patients with Medication-Induced Lupus Erythematosus, and also in 15 – 50% of patients with Rheumatoid Arthritis.

Sm

Positive/Negative

Antibodies against Sm are found in 10-40% of patients with Systemic Lupus Erythematosus (SLE). These antibodies have very high specificity of 99%.

RNP

 

 

Positive/Negative

Antibodies against RNP are found in 40-60% of patients with Mixed Connective Tissue Disease (MCTD, also known as Sharp Syndrome). These antibodies have 100% specificity to the disease.

Sm/RNP

Positive/Negative

Antibodies to Sm/RNP are found in patients with Mixed Connective Tissue Disease (MCTD, Sharp Syndrome) and Systemic Lupus Erythematosus (SLE).

SSA/Ro 60kD

Positive/Negative

Antibodies against SS-A/Ro are found in 40-80% of patients with Sjögren's Syndrome, in 50% of patients with Systemic Lupus Erythematosus (SLE), and in 90% of patients with Neonatal Lupus Erythematosus. These antibodies are also found in patients with Subacute Cutaneous Lupus Erythematosus.

SSA/Ro 52kD

Positive/Negative

Antibodies against SS-A/Ro are found in 40-80% of patients with Sjögren's Syndrome, in 50% of patients with Systemic Lupus Erythematosus (SLE), and in 90% of patients with Neonatal Lupus Erythematosus. These antibodies are also found in patients with Subacute Cutaneous Lupus Erythematosus.

SSB

Positive/Negative

Antibodies against SS-B are found in 40-80% of patients with Sjögren's  Syndrome, and in 90% of patients with Neonatal Lupus Erythematosus. These antibodies are also found in patients with Subacute Cutaneous Lupus Erythematosus.

Scl-70

Positive/Negative

Antibodies against Scl-70 are found in 60% of patients with Sclerdoderma. They are highly specific for the disease.

Ku

Positive/Negative

Antibodies against Ku are found in 5-25% of patients with Polymyositis/Scleroderma Overlap Syndrome.

PM-Scl 100

Positive/Negative

Antibodies against PM-Scl 100 are found in 20-25% of patients with Polymyositis/Scleroderma Overlap Syndrome. A reliable marker for Juvenile Scleromyositis.

Mi-2

Positive/Negative

Antibodies against Mi-2 are found in 25-35% of patients with Polymyositis/Dermatomyositis. Positive patients tend to have good prognosis.

Jo-1

Positive/Negative

Antibodies against Jo-1 are found in 60% of patients with Myositis and Fibrosing Alveolitis and in 30% of patients with Polymyositis/Dermatomyositis.

PL-7

Positive/Negative

Antibodies against PL-7 are found in 17% of patients with Polymyositis/Dermatomyositis.

PL-12

Positive/Negative

Antibodies against PL-12 are found in 3-6% of patients with Polymyositis/Dermatomyositis.

SRP-54

Positive/Negative

Antibodies against SRP 54 are found in 30% of patients with Polymyositis/Dermatomyositis. These antibodies are highly specific for polymyositis.

Ribosome P Protein (RPP)

Positive/Negative

Antibodies against Ribosomal P Protein are found in 10-35% of patients with Systemic Lupus Erythematosus (SLE) and have a high specificity of 99%.

CENP-A/B

Positive/Negative

Antibodies against CENP-A/B are usually associated with CREST Syndrome, and their prevalence is 57 – 82%.

Proliferating Cell Nuclear Antigen (PCNA)

Positive/Negative

Antibodies against Proliferating Cell Nuclear Antigen are found in 3% of patients with Systemic Lupus Erythematosus (SLE) but are highly specific to the disease.

sp100

Positive/Negative

Antibodies against sp100 are found in 27% of patients with Primary Biliary Cirrhosis (PBC). This antigen is of importance in assessing PBC patients negative for mitochondrial antibodies.

gp210

Positive/Negative

Antibodies against gp210 are found in 10-25% of patients with Primary Biliary Cirrhosis (PBC). This antigen is of importance in assessing PBC patients negative for mitochondrial antibodies.

M2 recombinant

Positive/Negative

Antibodies against mitochondrial antigens are found in 95% of patients with Primary Biliary Cirrhosis.

M2/nPDC

Positive/Negative

Antibodies against mitochondrial native PDC are found in 95% of patients with Primary Biliary Cirrhosis.

F-actin

Positive/Negative

Antibodies against F-actin are found in 25% of patients with Autoimmune Hepatitis type 1. These antibodies are the main component of the broad family of Smooth Muscle Abs (SMA).

 



Forgot Password?